Tramadol for Treatment of Pain in Cats

a href="http://www.ncbi.nlm.nih.gov/pubmed/19951117?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumordinalpos=1"Pypendop BH, Siao KT, Ilkiw JE. Effects of tramadol hydrochloride on the thermal threshold in cats. Am J Vet Res. Dec 2009;70(12):1465-1470./abr / br / Tramadol is a centrally acting analgesic agent that is increasingly being used to treat pain in cats, though limited data are available on analgesic efficacy. Six healthy adult cats were used in this study to determine the thermal antinociceptive effect of the oral administration of tramadol at doses between 0.5 and 4 mg/kg in cats. An antinociceptive effect refers to reduction of sensitivity to painful stimuli. Results showed that doses of 2 mg/kg and higher were necessary to yield a significant and sustained effect. All six cats exhibited mydriasis (dilated pupils) after administration of 3 and 4 mg/kg. Three of the six cats appeared to have a facial itch at different doses of 2, 3, and 4 mg/kg, respectively. No clinically important adverse effect was observed in the cats though this study was not designed to assess the safety of tramadol in cats. This study suggests that a dose of 4 mg/kg given every 6 hours will maintain analgesia close to the maximum effect of tramadol. [VT]br / br / bRelated articles:/bbr / a href="http://www.ncbi.nlm.nih.gov/pubmed/19233698?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumordinalpos=3"Brondani JT, Loureiro Luna SP, Beier SL, Minto BW, Padovani CR. Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy. Journal of Feline Medicine Surgery. 2009;11(6):420-429./abr / br / a href="http://www.ncbi.nlm.nih.gov/pubmed/18177319?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumordinalpos=6"Pypendop BH, Ilkiw JE. Pharmacokinetics of tramadol, and its metabolite O-desmethyl-tramadol, in cats. J Vet Pharmacol Ther. Feb 2008;31(1):52-59./abr / br / More on cat health: a href="http://www.winnfelinehealth.org/Health.html"Winn Feline Foundation Library/abr / a href="http://www.facebook.com/WinnFelineFoundation"Join us on Facebook/abr / a href="http://www.twitter.com/WinnFeline"Follow us on Twitter/abr / br / New for 2010: a href="http://winnfelinehealth.us1.list-manage.com/subscribe?u=415b3f2ea14ea9e3390df93aaid=cb095b8233"Subscribe to our e-newsletter/adiv class="blogger-post-footer"Providing expert cat health information and supporting cat health research since 1968.img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/1170470470666539402-1560396244155972655?l=winnfelinehealth.blogspot.com' alt='' //divdiv class="feedflare" a href="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?a=plsPMbXeYVA:ouilXc9ZZm4:yIl2AUoC8zA"img src="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?d=yIl2AUoC8zA" border="0"/img/a a href="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?a=plsPMbXeYVA:ouilXc9ZZm4:UT3xtbGYFzA"img src="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?d=UT3xtbGYFzA" border="0"/img/a a href="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?a=plsPMbXeYVA:ouilXc9ZZm4:qj6IDK7rITs"img src="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?d=qj6IDK7rITs" border="0"/img/a a href="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?a=plsPMbXeYVA:ouilXc9ZZm4:F7zBnMyn0Lo"img src="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?i=plsPMbXeYVA:ouilXc9ZZm4:F7zBnMyn0Lo" border="0"/img/a a href="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?a=plsPMbXeYVA:ouilXc9ZZm4:V_sGLiPBpWU"img src="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?i=plsPMbXeYVA:ouilXc9ZZm4:V_sGLiPBpWU" border="0"/img/a a href="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?a=plsPMbXeYVA:ouilXc9ZZm4:oCFASsrFxfc"img src="http://feeds.feedburner.com/~ff/CatHealthNewsFromTheWinnFelineFoundation?d=oCFASsrFxfc" border="0"/img/a /divimg src="http://feeds.feedburner.com/~r/CatHealthNewsFromTheWinnFelineFoundation/~4/plsPMbXeYVA" height="1" width="1"/

Pain Control for Spay Surgery in Cats

Brondani JT, Loureiro Luna SP, Beier SL, Minto BW, Padovani CR. Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy. J Feline Med Surg 2009; 11: 420-9.

Veterinarians now recognize that preventive pain control is beneficial for cats undergoing surgery, providing comfort and faster recoveries. One of the most common feline surgeries is the ovariohysterectomy or spay. The researchers investigated the efficacy of two drugs, tramadol and vedaprofen, in 40 female cats undergoing spay surgery. The cats were divided into four treatment groups: vedaprofen only, tramadol only, vedaprofen plus tramadol, and placebo. Medications were administered one hour before surgery and for 72 hours after surgery. Pain scores were evaluated at regular intervals for the first 96 hours and then on day 7 after surgery. Cats with high pain scores were given rescue analgesia with morphine. Cats treated with vedaprofen and tramadol together did not require rescue analgesia and proved to be the most effective option evaluated. Multimodal analgesia is known to be a superior method of pain control and proved effective for cats undergoing spay surgery. The researchers recommended that pain control should be provided for a minimum of three days after spay surgery. [SL]
>> PubMed Abstract

Related articles:
Slingsby L, Waterman-Pearson A. Postoperative analgesia in the cat after ovariohysterectomy by use of carprofen, ketoprofen, meloxicam or tolfenamic acid. J Small Anim Pract 2000; 41: 447-450.
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Tobias KM, Harvey RC, Byarlay JM. A comparison of four methods of analgesia in cats following ovariohysterectomy. Vet Anaesth Analg 2006; 33: 390-8.
>> PubMed Abstract

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