Intestinal Biopsies in Cats
April 8th, 2010 | Comments Off | Posted in inflammatory bowel disease, large granular lymphocyte lymphoma
a href="http://www.ncbi.nlm.nih.gov/pubmed/19664949"Kleinschmidt S, Harder J, Nolte I et al: Chronic inflammatory and non-inflammatory diseases of the gastrointestinal tract in cats: diagnostic advantages of full-thickness intestinal and extraintestinal biopsies, J Feline Med Surg 12:97, 2010./abr /
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Forty-three cats with chronic gastrointestinal disease signs had histologic evaluation of full-thickness biopsies from the gastrointestinal tract (GIT) and extraintestinal samples. The GIT samples were one biopsy taken from the fundus of the stomach, duodenum, mid-jejunum, ileum, and descending colon. Extraintestinal samples were collected from the liver, pancreas, mesenteric lymph node, and mesentery. In all the cats, chronic gastrointestinal signs (vomiting, diarrhea, and anorexia) had been present for at least 3 weeks up to 1 year. In 42 of 43 cats, findings revealed different histopathological gastrointestinal alterations on full thickness biopsy, with inflammatory lesions being the most frequent alteration (46.5%). Ten of the 43 cases (23.3%) had diffuse lymphoma diagnosed. In many cases, the demonstration of transmural spread of the neoplastic lymphoid cells is a very helpful method of diagnosing a neoplastic infiltration of the intestinal wall. The mesenteric lymph nodes and liver are frequently involved in cases of diffuse intestinal lymphoma and should be sampled during the laparotomy procedure. Extraintestinal samples are helpful in diagnosing intestinal tumors such as lymphoma and ones of mast cell origin. [VT]br /
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bRelated articles:/bbr /
a href="http://www.ncbi.nlm.nih.gov/pubmed/19576832"Lingard AE, Briscoe K, Beatty JA et al: Low-grade alimentary lymphoma: clinicopathological findings and response to treatment in 17 cases, Journal of Feline Medicine Surgery 11:692, 2009./abr /
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Probiotics for Cats
April 2nd, 2009 | Comments Off | Posted in Lactobacillus, diarrhea, immunity, inflammatory bowel disease, probiotic
Wynn, S. G. (2009). "Probiotics in veterinary practice." Journal of the American Veterinary Medical Association 234(5): 606-613.The definition of a probiotic is one of several “live microorganisms which when administered in adequate amounts confer a health benefit on the host.” Probiotics have luminal and mucosal effects in the gastrointestinal tract. The gastrointestinal tract is the largest immune organ of the body. Mucosal effects would include interactions with immune cells and enterocytes. Luminal effects include chemical changes in ingesta and mucus as a result of the probiotic activity. Cats and dogs have high numbers of bacteria in the proximal portion of the gastrointestinal tract, more so than seen in humans. Cat feces contain high number of anaerobic bacteria, so the effect of Lactobacillus acidophilus has been evaluated in the cat. The use of probiotics clearly seems to enhance immune function in cats and seems to have a role in the treatment of certain gastrointestinal conditions (e.g., inflammatory bowel disease and diarrhea). Other clinical effects are still being considered. However, probiotic products have a large variation in quality control and the safety factor is still being evaluated. [VT]
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Related articles:
Weese, J. S. (2002). "Microbiologic evaluation of commercial probiotics." J Am Vet Med Assoc 220(6): 794-7.
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Weese, J. S. (2003). "Evaluation of deficiencies in labeling of commercial probiotics." Can Vet J 44(12): 982-3.
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Endoscopy for Diagnosis of Gastrointestinal Disease in Cats
November 6th, 2008 | Comments Off | Posted in endoscopy, gastrointestinal biopsy, inflammatory bowel disease, lymphoma
Willard, M. D., J. Mansell, et al. (2008). "Effect of sample quality on the sensitivity of endoscopic biopsy for detecting gastric and duodenal lesions in dogs and cats." Journal of Veterinary Internal Medicine 22(5): 1084-1089.A common diagnostic procedure for assessment of chronic gastrointestinal disease in cats is endoscopy with biopsies of gastrointestinal mucosa. Previous studies have highlighted the difficulty in obtaining quality biopsy samples via endoscopy. In this study, the researchers attempted to address two issues: whether the ability to demonstrate a histologic lesion in the stomach or duodenum is affected by sample quality, and whether more samples are needed to find a lesion when tissue specimens are of poor quality. The researchers evaluated tissues obtained via endoscopy from 51 cats (and 99 dogs) that were examined as clinical cases at 8 veterinary institutions or practices in 5 different countries. The results showed that the quality of endoscopically obtained tissue samples has a profound effect on their sensitivity for identifying certain lesions, and there are differences between biopsies of canine and feline tissues. Multiple samples need to be taken to ensure that a sufficient number of adequate tissue samples are obtained during endoscopic procedures. The old assumption that a single adequate biopsy sample is sufficient for diagnosis was shown to be incorrect. The study suggests that a goal of obtaining 6 marginal or adequate feline duodenal or gastric samples will be sufficient to give 99% confidence of finding any lesions present.
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Related articles:
Day, M. J., T. Bilzer, et al. (2008). "Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group." J Comp Pathol 138 Suppl 1: S1-43.
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Evans, S. E., J. J. Bonczynski, et al. (2006). "Comparison of endoscopic and full-thickness biopsy specimens for diagnosis of inflammatory bowel disease and alimentary tract lymphoma in cats." J Am Vet Med Assoc 229(9): 1447-50.
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