My cat has had loose stool issues for years. We have gone to four different vets and…

I feel for you. I have also had a cat with chronic loose stool issues. One approach is to try to get to the bottom of why this is happening. If you have been to multiple vets, I would assume at least a general baseline of labs etc. have been done. If those are all normal, I consider a couple additional tests. A blood test to look at folate and vitamin B12 levels as well as a test called a TLI can be helpful in cats with diarrhea. Abnormalities in folate or B12 levels can help us know where disease may be lurking and also what additional treatments can be done. In many cases, biopsies of the intestines taken through endoscopy or surgery are needed to give us an answer. Many cats have what we call Inflammatory Bowel Disease (IBD) and biopsy is the best way to diagnose this.

Another option is to continue to try medications for the symptoms. If you've done food trials, I would want to be sure you've done a limited ingredient diet for at least eight weeks with absolutely no other food or treats during that time. It can be very difficult to do this and one slip up with extra food can throw it all off. Another treatment option I would throw out there is an oral anti-inflammatory like prednisolone. This corticosteroid is usually the mainstay treatment for inflammatory bowel disease and can often make a big difference in the treatment of chronic diarrhea. Cats tend to have minimal side effects with steroids (compared with people or other animals) and do very well. Hope this helps and that you can find some relief for your cat.